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December 4, 2025Clinical Infectious Diseases

Rabies Despite Post-Exposure Prophylaxis in High-Burden Settings: Vaccine Failure or Gaps in Healthcare Delivery?

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Authors

SCShubhangi ChandelRMReeta S. Mani

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Overview

Retrospective analysis reveals low rabies breakthrough infections among patients, suggesting gaps in post-exposure prophylaxis delivery.

Key Points

  • True rabies breakthrough infections are rare, with only 3 reported cases among 89 analysed.
  • The majority of rabies exposure occurred in males under 15 years, predominantly from dog bites.
  • Retrospective analysis of laboratory-confirmed rabies cases highlights the importance of timely post-exposure prophylaxis implementation.
  • Findings emphasize the need for improved healthcare delivery to prevent rabies following exposures.

Cite This Study

Chandel et al. (2025) studied this question.

synapsesocial.com/papers/694023fa2d562116f28fdbefhttps://doi.org/10.1093/cid/ciaf662
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Critical Need for a Comprehensive Post-Exposure Care Bundle following Rabies Exposure: A Report of Two Cases2026
  2. 2Circulating Antibody’s Role During Post-Exposure Prophylaxis, and Beyond for Rabies: A Review2025
  3. 3Rabies post-exposure prophylaxis in adult patients presenting to the emergency department: A retrospective study2025
  4. 4Rabies Encephalitis following Post Exposure prophylaxis (PEP) is becoming an evolving problem in Bangladesh.2024 · 3 citations
  5. 5Rabies postexposure prophylaxis protocol option for unvaccinated domestic animals, Texas: 2010–20192024 · 2 citations