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June 19, 2026American Journal of Tropical Medicine and Hygiene

The Critical Need for a Comprehensive Post-Exposure Care Bundle following Rabies Exposure: A Report of Two Cases

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Authors

JYJayanthi YadavAKAtul S. KecheLLLonika Lodha

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Overview

Two cases demonstrate critical failures in rabies post-exposure care, highlighting the need for improved management practices.

Key Points

  • To emphasize the importance of a comprehensive rabies care bundle for preventing fatal outcomes after exposure.
  • Reported two cases of rabies fatalities due to inadequate post-exposure prophylaxis, particularly failures in wound care and immunization.
  • Verified rabies infections through histopathological and molecular analyses.
  • Highlighted critical shortcomings in care such as poor wound management and lack of rabies immunoglobulin administration.
  • Both patients suffered fatal outcomes despite vaccination due to inadequate post-exposure care components.
  • Key failures included improper wound suturing and failure to administer rabies immunoglobulin.
  • Findings indicate an urgent need for adherence to WHO guidelines and enhanced clinician awareness.

Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/6a34dbc465a5b0777af2c63fhttps://doi.org/10.4269/ajtmh.25-0649
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rabies Despite Post-Exposure Prophylaxis in High-Burden Settings: Vaccine Failure or Gaps in Healthcare Delivery?2025 · 2 citations
  2. 2Circulating Antibody’s Role During Post-Exposure Prophylaxis, and Beyond for Rabies: A Review2025
  3. 3Rabies Encephalitis following Post Exposure prophylaxis (PEP) is becoming an evolving problem in Bangladesh.2024 · 3 citations
  4. 41477: EXPOSURE IN THE ICU: NAVIGATING RABIES RISK AND POST-EXPOSURE PROPHYLAXIS FOR HEALTHCARE WORKERS2026
  5. 5Rabies: Is it Possible to Treat?2024