Shows improvement in retinal health in diabetic mice, suggesting potential therapeutic benefits.
AIMS: mice. In db/db mice treated systemically for 20 weeks, PA reduced Evans Blue leakage, increased retinal thickness, restored RPE tight junction proteins, and normalized mitochondrial architecture by transmission electron microscopy. PA rebalanced mitochondrial dynamics (dynamin 1-like, optic atrophy 1, fission 1, mitofusin 1, FUN14 domain containing 1), increased retinal mitochondrial DNA copy number, and partially stabilized glycemia and weight. CONCLUSION: 00, 000-000.
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Xiao et al. (2026) studied this question.
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