Randomized trial reveals antibacterial and antibiofilm properties of silver nanoparticles from Sarcochlamys pulcherrima, suggesting potential use in medicine.
Key Points
This research aims to synthesize and evaluate silver nanoparticles using Sarcochlamys pulcherrima for their antibacterial and antibiofilm properties.
Synthesis of silver nanoparticles (sp-AgNPs) using Sarcochlamys pulcherrima leaf extract via heating and non-heating methods.
Characterization of sp-AgNPs using UV-Vis spectroscopy, EDX, DLS, Zeta Potential, and SEM techniques.
Evaluation of antibacterial efficacy and biofilm inhibition against B.subtilis, S.aureus, P.aeruginosa, and E.coli.
Silver nanoparticles exhibited inhibitory zones against all tested bacteria, with MIC and MBC evaluated.
Non-heating method achieved a biofilm inhibition of 67.51–83.14%, outperforming the heating method which had 50.93–73.76% reduction.
Network pharmacology analysis identified key phytoconstituents targeting immune pathways such as AKT1, STAT3, and CASP3.