May 23, 2017Ultrasound in Obstetrics and Gynecology
Improved technical success, postnatal outcome and refined predictors of outcome for fetal aortic valvuloplasty
Why the study?
Does fetal aortic valvuloplasty in a more recent era improve the rate of biventricular outcome at neonatal discharge compared to an earlier era in fetuses with evolving HLHS?
Population
123 fetuses with evolving hypoplastic left heart syndrome undergoing fetal aortic valvuloplasty at Boston…
Comparison
Fetal aortic valvuloplasty in the recent era vs Fetal aortic valvuloplasty in the earlier era
Design
Cohort
Follow-up
Until neonatal hospital discharge
Authors
Discussion
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Member takes
Implication
Higher recent-era biventricular rates after fetal aortic valvuloplasty are hypothesis-generating; prospective trials needed before changing practice in evolving HLHS.
Structured PICO
Does fetal aortic valvuloplasty in a more recent era improve the rate of biventricular outcome at neonatal discharge compared to an earlier era in fetuses with evolving HLHS?
P
Population
123 fetuses with evolving hypoplastic left heart syndrome (HLHS) undergoing fetal aortic valvuloplasty (FAV) at Boston Children's Hospital between 2000 and 2015
I
Intervention
Fetal aortic valvuloplasty in the recent era (2009-2015, n=52)
C
Comparator
Fetal aortic valvuloplasty in the earlier era (2000-2008, n=71)
O
Outcome
Circulation type (biventricular vs single ventricle) at the time of neonatal hospital dischargehard clinical
Fetal aortic valvuloplasty for evolving HLHS has shown improved technical success and higher rates of biventricular circulation at neonatal discharge in the recent era, with specific fetal echocardiographic parameters predicting success.
Cite This Study
Friedman et al. (2017) studied this question.