Why the study?
Altered insulin signaling in the heart may contribute to ventricular remodeling and heart failure progression, highlighting the need to review its physiological and pathological roles.
Key points are not available for this paper at this time.
Design
Review article
Cautions against targeting cardiac insulin signaling in practice; leaves open whether modulation alters HF progression in obesity or diabetes.
Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial metabolism. Insulin signaling modulates the cardiac responses to physiological and pathological stressors. Altered insulin signaling in the heart may contribute to the pathophysiology of ventricular remodeling and heart failure progression. Myocardial insulin signaling adapts rapidly to changes in the systemic metabolic milieu. What may initially represent an adaptation to protect the heart from carbotoxicity may contribute to amplifying the risk of heart failure in obesity and diabetes. This review article presents the multiple roles of insulin signaling in cardiac physiology and pathology and discusses the potential therapeutic consequences of modulating myocardial insulin signaling.
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E. Dale Abel (2021) studied this question.
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