Why the study?
Does the presence of a KCNJ5 mutation predict the resolution of hypertension after unilateral adrenalectomy in patients with aldosterone-producing adenoma?
Population
142 patients with aldosterone-producing adenoma (APA) and hypertension
Comparison
Presence of somatic KCNJ5 mutation in APA tissue vs Wild-type KCNJ5
Design
Cohort
Follow-up
1 year
Authors
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KCNJ5 mutations were associated with hypertension cure after adrenalectomy in APA; hypothesis-generating and requires prospective validation before guiding practice.
Does the presence of a KCNJ5 mutation predict the resolution of hypertension after unilateral adrenalectomy in patients with aldosterone-producing adenoma?
Somatic KCNJ5 mutations in aldosterone-producing adenomas are an independent predictor for the resolution of hypertension and regression of left ventricular hypertrophy following unilateral adrenalectomy.
Kitamoto et al. (2017) studied this question.
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