Longitudinal cohort study reveals increased mortality risk in type 2 diabetes patients with shrunken pore syndrome and normal renal function, suggesting value in early risk assessment.
AIMS/HYPOTHESIS: ratio (<0.60), reflecting a pathological glomerular state termed shrunken pore syndrome (SPS), has been associated with excess mortality in some clinical situations including diabetes. The aim of the present study was to explore this association in a longitudinal observational study of type 2 diabetes with special reference to participants with normal renal function. METHODS: and urinary albumin/creatinine ratio <3 mg/mmol) at baseline. RESULTS: ratio <0.60, observed in 57 (7.6%), was also independently associated with mortality (HR [95% CI] 2.55 [1.34, 4.84], p=0.004). CONCLUSIONS/INTERPRETATION: ratio is independently associated with mortality in type 2 diabetes, including in people without conventional markers of diabetic kidney disease. The presence of SPS may add clinical value to the risk assessment of people with type 2 diabetes regardless of renal status.
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Bruce et al. (2025) studied this question.
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