What question did this study set out to answer?

This research aims to explore the connection between shrunken pore syndrome and right ventricular systolic function in heart failure patients.

September 13, 2016Scandinavian Journal of Clinical and Laboratory InvestigationOpen Access

The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population – the HARVEST study

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Heart failure (n=95). Intervention: Shrunken pore syndrome vs. Absence of shrunken pore syndrome. Primary outcome: Right ventricular systolic function (TAPSE and RV S').

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Key result

Shrunken pore syndrome was significantly associated with declined right ventricular systolic function (TAPSE and RV S') in patients hospitalized for heart failure.

Why the study?

Is the 'Shrunken pore syndrome' associated with declined right ventricular systolic function in patients hospitalized for heart failure?

Population

95 patients hospitalized for heart failure who underwent transthoracic echocardiograms from the HARVEST study

Comparison

Presence of 'Shrunken pore syndrome' vs Absence of 'Shrunken pore syndrome'

Design

Cohort

Authors

ACAnders ChristenssonMalmö University AGAnders GrubbSkåne University Hospital JMJohn MolvinHeart Failure & Transplant

Discussion

Member takes

Implication

Shrunken pore syndrome may mark RV systolic impairment in hospitalized HF; hypothesis-generating association requires prospective validation before clinical use.

Key Points

This research aims to explore the connection between shrunken pore syndrome and right ventricular systolic function in heart failure patients.
Patients were selected from the HARVEST trial (N=95) with heart failure and underwent transthoracic echocardiograms (TTE).
Four formulas for estimated glomerular filtration rate (eGFR) were utilized to diagnose shrunken pore syndrome: CKD-EPI creatinine, CKD-EPI cystatin C, LMrev, and CAPA.
Linear regression analysis was performed, adjusting for age and sex to evaluate the relationship between shrunken pore syndrome and echocardiographic parameters.
Heart failure patients with shrunken pore syndrome exhibited significant declines in right ventricular systolic function measurements (TAPSE and RV S').
The presence of shrunken pore syndrome indicated a statistically significant association with right ventricular dysfunction (p-value not specified).
Patients without shrunken pore syndrome appeared to have a protective effect against right ventricular systolic dysfunction.

Study Design

Type

Cross-Sectional (n=95)

Structured PICO

Is the 'Shrunken pore syndrome' associated with declined right ventricular systolic function in patients hospitalized for heart failure?

Population

95 patients hospitalized for heart failure who underwent transthoracic echocardiography.

Exposure

Presence of 'Shrunken pore syndrome' (defined as eGFR cystatin C ≤ 60% of eGFR creatinine)

Comparator

Absence of 'Shrunken pore syndrome' (defined as eGFR cystatin C >90% and <110% of eGFR creatinine)

Outcome

Echocardiographic parameters of right ventricular (RV) systolic function (TAPSE and RV S')surrogate

In patients hospitalized for heart failure, the presence of 'Shrunken pore syndrome' is significantly associated with right ventricular systolic dysfunction.

Cite This Study

Christensson et al. (2016) conducted a cross-sectional in Heart failure (n=95). Shrunken pore syndrome vs. Absence of shrunken pore syndrome was evaluated on Right ventricular systolic function (TAPSE and RV S'). Shrunken pore syndrome was significantly associated with declined right ventricular systolic function (TAPSE and RV S') in patients hospitalized for heart failure.

synapsesocial.com/papers/6a227f1bf6fb2c59e553e572 https://doi.org/10.1080/00365513.2016.1223338

Topics

Heart failure HFrEF treatment Echocardiography

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Implication

Shrunken pore syndrome may mark RV systolic impairment in hospitalized HF; hypothesis-generating association requires prospective validation before clinical use.

The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population – the HARVEST study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population – the HARVEST study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider