Why the study?
What are the vascular structural and functional changes in small arteries of patients with type 2 diabetes compared to hypertensive and normotensive controls?
Population
Patients with type 2 diabetes mellitus, untreated patients with essential hypertension, and normotensive…
Comparison
In vitro examination of small arteries using… vs Normotensive nondiabetic control subjects and…
Design
Cross-sectional
Authors
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Small-artery hypertrophy and myogenic loss in type 2 diabetes may signal higher risk; cross-sectional data leave mechanisms and therapies open.
What are the vascular structural and functional changes in small arteries of patients with type 2 diabetes compared to hypertensive and normotensive controls?
Type 2 diabetes is associated with vascular hypertrophy and impaired myogenic responsiveness in small arteries, with endothelial dysfunction partly attributable to dyslipidemia.
Schofield et al. (2002) studied this question.
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