Inhibitor Ap5A demonstrates competitive inhibition of adenylate kinase in rabbit muscle, indicating potential biochemical applications.
Rabbit muscle adenylate kinase is potently inhibited by P1,P5-di(adenosine-5')pentaphosphate (Ap5A) but not by the homologs of this compound with fewer phosphoryl groups in the polyphosphate bridge and not by adenosine 5'-pentaphosphate. The inhibition by Ap5A is competitive with respect to both of the substrates, AMP and ATP. The association constant for the binding of Ap5A to adenylate kinase is about 4 x 108 m-1 at 24° and pH 8.0.
No takes yet. Share an insight, caveat, or question.
Lienhard et al. (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: