Population
Langendorff-perfused rabbit hearts and rabbit atrial myocytes
Comparison
Diadenosine pentaphosphate perfusion vs Control (baseline without Ap5A)
Design
Preclinical
Authors
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Ap5A proarrhythmia in rabbit atria should not change practice; hypothesis-generating for A1-mediated AF facilitation in humans.
Diadenosine pentaphosphate exerts A1-receptor-mediated proarrhythmic effects in rabbit atrial myocardium, likely via hydrolysis to adenosine, which reduces atrial effective refractory period and facilitates atrial fibrillation.
Brandts et al. (2003) studied this question.
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