Key result
Diadenosine polyphosphates significantly reduced coronary perfusion pressure (from 36.5 to 18.6 mm Hg, p<0.001) and altered electrophysiologic variables in isolated guinea-pig hearts.
Population
Isolated guinea-pig hearts
Comparison
Diadenosine triphosphate, tetraphosphate… vs Adenosine, adenosine triphosphate, and baseline…
Design
Preclinical
Authors
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These effects in isolated guinea-pig hearts warrant caution before human translation; hypothesis-generating for coronary and electrophysiologic actions.
Absolute Event Rate: 18.6% vs 36.5%
p-value: p=< 0.001
Diadenosine polyphosphates exert potent coronary vasomotor and cardiac electrophysiologic effects via purinergic receptors, suggesting a potential role during platelet activation in acute coronary syndromes.
Stavrou et al. (2001) studied Coronary vasomotor and cardiac electrophysiologic effects. Diadenosine polyphosphates (Ap3A, Ap4A, Ap5A, Ap6A) and nonhydrolyzable analogs vs. Adenosine, adenosine triphosphate, and baseline was evaluated on Coronary perfusion pressure (p=< 0.001). Diadenosine polyphosphates significantly reduced coronary perfusion pressure (from 36.5 to 18.6 mm Hg, p<0.001) and altered electrophysiologic variables in isolated guinea-pig hearts.
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