Key result
Diadenosine tetraphosphate (AP4A) dilated coronary arterioles dose-dependently, with greater dilatation in smaller vessels (24.5% vs 10.6% in large vessels at 1,000 micromol/L, p<0.001).
Population
Open chest dogs (canine model)
Comparison
Diadenosine tetraphosphate superfusion or infusion vs Baseline and co-administration of purinoceptor…
Design
Preclinical
Authors
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AP4A exerts bidirectional effects on canine coronary microvessels; leaves open its net role in human platelet-mediated microvascular regulation.
p-value: p=<0.001
AP4A exerts bidirectional effects on coronary arterial microvessels, causing P1 purinoceptor- and NO-mediated vasodilation and non-P2X-mediated vasoconstriction.
Sugimura et al. (2000) studied this question. Diadenosine tetraphosphate (AP4A) vs. Baseline and various purinoceptor/NO blockers was evaluated on Coronary arterial microvessel dilatation (p=<0.001). Diadenosine tetraphosphate (AP4A) dilated coronary arterioles dose-dependently, with greater dilatation in smaller vessels (24.5% vs 10.6% in large vessels at 1,000 micromol/L, p<0.001).
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