Population
Isolated, saline-perfused segments of rabbit mesenteric arteries precontracted with norepinephrine
Comparison
Diadenosine triphosphate and diadenosine… vs Endothelium-intact vs endothelium-denuded…
Design
Preclinical
Authors
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Differential endothelial dependence of AP3A/AP4A effects in rabbit arteries is hypothesis-generating; prospective human studies needed before clinical consideration.
AP3A and AP4A act directly on endothelial and/or smooth muscle receptors to modulate vascular tone in rabbit mesenteric arteries, with AP4A's dilator effect being endothelium-dependent.
Busse et al. (1988) studied this question.
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