Why the study?
Does atriopeptin III affect the lumen diameter of isolated rat afferent and efferent arterioles?
Population
Isolated afferent (AA) and efferent arterioles (EA) from rat kidneys
Comparison
Atriopeptin III (AP III) (10(-13)-10(-7) M) vs Baseline or preconstricted state
Design
Preclinical
Authors
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Should not yet change practice; leaves open net glomerular hemodynamic effects in vivo.
Does atriopeptin III affect the lumen diameter of isolated rat afferent and efferent arterioles?
Atriopeptin III exhibits differential vasoactive effects on renal microvasculature, dilating preconstricted afferent arterioles while constricting efferent arterioles.
Lanese et al. (1991) studied this question.
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