Why the study?
Does rat atriopeptin III stimulate Na/K/Cl cotransport via cGMP in vascular smooth muscle cells?
Population
Primary cultures of vascular smooth muscle cells (VSMC) derived from explants of rat thoracic aorta
Comparison
Rat atriopeptin III at various concentrations… vs Untreated cells (basal conditions)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether cGMP-cotransport mediates ANF vasorelaxation in vivo.
Does rat atriopeptin III stimulate Na/K/Cl cotransport via cGMP in vascular smooth muscle cells?
Rat atriopeptin III stimulates Na/K/Cl cotransport in vascular smooth muscle cells via elevations in cGMP, suggesting a cellular mechanism for ANF-mediated vasorelaxation.
O’Donnell et al. (1986) studied this question.
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