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November 1, 1986Journal of Biological ChemistryOpen Access

Role of cyclic GMP in atrial natriuretic factor stimulation of Na+,K+,Cl- cotransport in vascular smooth muscle cells.

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Population

Vascular smooth muscle cells (VSMC) from primary cultures of rat thoracic aorta

Comparison

Atrial natriuretic factor, LY83583… vs Untreated cells (basal conditions)

Design

Preclinical

Authors

MOMartha E. O’DonnellUniversity of California, DavisNON. E. OwenRosalind Franklin University of Medicine and Science

Discussion

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Implication

No immediate clinical implications from this animal study; extends mechanistic evidence for cGMP-mediated vascular ion transport.

Structured PICO

P
Population
Vascular smooth muscle cells (VSMC) from primary cultures of rat thoracic aorta
I
Intervention
Atrial natriuretic factor (rat atriopeptin III 100 nM), LY83583 (10 microM), 8-bromo-cGMP, and M&B 22,948
C
Comparator
Untreated cells (basal conditions)
O
Outcome
Na+,K+,Cl- cotransport activitysurrogate

Atrial natriuretic factor stimulates Na+,K+,Cl- cotransport in vascular smooth muscle cells via an increase in intracellular cGMP levels.

Cite This Study

O’Donnell et al. (1986) studied this question.

synapsesocial.com/papers/6a198a468ef0a4da5e8dfa6fhttps://doi.org/10.1016/s0021-9258(18)66734-1
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues.1984 · 262 citations
  2. 2Atrial natriuretic factor stimulates Na/K/Cl cotransport in vascular smooth muscle cells.1986 · 53 citations
  3. 3Atrial Natriuretic Factor: A Hormone Produced by the Heart1985 · 989 citations
  4. 4Differing effects of cGMP and cAMP on ion transport across flounder intestine1984 · 71 citations