Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1990AJP Renal Physiology

Atrial peptide and cGMP effects on NaCl transport in inner medullary collecting duct

View Full Paper
Ask AI
Bookmark
Share

Population

In vitro microperfused inner medullary collecting ducts (IMCD) isolated from rat kidneys

Comparison

Atrial natriuretic factor and guanosine… vs Baseline conditions without ANF/cGMP, and…

Design

Preclinical

Authors

ARAntonino S. RochaUniversidade de São PauloLKLúcia H. KudoOklahoma State University at Tulsa

Discussion

Loading...

Member takes

Implication

Does not support clinical translation; leaves open human relevance of cGMP-mediated tubular effects.

Structured PICO

P
Population
In vitro microperfused inner medullary collecting ducts (IMCD) isolated from rat kidneys
I
Intervention
Atrial natriuretic factor (ANF) and guanosine 3',5'-cyclic monophosphate (cGMP) added to bath
C
Comparator
Baseline conditions without ANF/cGMP, and conditions with vasopressin, furosemide, or ion replacement
O
Outcome
Na+ and Cl- transport (isotopic fluxes, net absorption, and lumen potential difference)surrogate

ANF directly inhibits Na+ and Cl- absorption in the inner medullary collecting duct via cGMP-mediated mechanisms, providing insight into its natriuretic effects.

Cite This Study

Rocha et al. (1990) studied this question.

synapsesocial.com/papers/6a88eb7b8642fe04be696be4https://doi.org/10.1152/ajprenal.1990.259.2.f258
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.1988 · 119 citations
  2. 2Hormone effects on NaCl permeability of rat inner medullary collecting duct1988 · 53 citations
  3. 3Role of cyclic GMP in atrial natriuretic factor stimulation of Na+,K+,Cl- cotransport in vascular smooth muscle cells.1986 · 86 citations
  4. 4Effects of ANF on cGMP synthesis in inner medullary collecting duct subsegments of rats1990 · 13 citations
  5. 5Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin1989 · 47 citations