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November 1, 1989AJP Renal Physiology

Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin

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Why the study?

Does atrial natriuretic factor (ANF) regulate fluid absorption in rat proximal straight tubules, and is this effect dependent on angiotensin?

Population

Isolated perfused proximal straight tubules of rats

Comparison

Atrial natriuretic factor at 10 M or 2 X 10 M… vs ANF alone vs ANF in the presence of angiotensin…

Design

Preclinical

Authors

JGJeffrey L. GarvinUniversity School

Discussion

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Overview

ANF may inhibit proximal reabsorption only with angiotensin II present in rats; leaves open translation to human cardiorenal physiology.

Structured PICO

Does atrial natriuretic factor (ANF) regulate fluid absorption in rat proximal straight tubules, and is this effect dependent on angiotensin?

P
Population
Isolated perfused proximal straight tubules of rats
I
Intervention
Atrial natriuretic factor (ANF) at 10(-8) M or 2 X 10(-10) M, with or without angiotensin II (1.6 X 10(-10) M); dibutyryl-cGMP (DBcGMP)
C
Comparator
ANF alone vs ANF in the presence of angiotensin II; baseline fluid absorption
O
Outcome
Fluid absorption (Jv)surrogate

Atrial natriuretic factor inhibits fluid absorption in the rat proximal straight tubule only in the presence of angiotensin, an effect likely mediated by cGMP.

Cite This Study

Jeffrey L. Garvin (1989) studied this question.

synapsesocial.com/papers/6a843ce1c2c8a33f31f7a05ehttps://doi.org/10.1152/ajprenal.1989.257.5.f907
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANF inhibits norepinephrine-stimulated fluid absorption in rat proximal straight tubules1992 · 12 citations
  2. 2ANF and angiotensin II interact via kinases in the proximal straight tubule1995 · 24 citations
  3. 3ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney1989 · 82 citations
  4. 4Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.1988 · 119 citations
  5. 5Inhibition of proximal tubular fluid absorption by nitric oxide and atrial natriuretic peptide in rat kidney1998 · 93 citations