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January 1, 1989AJP Renal Physiology

ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney

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Why the study?

Does ANF inhibit net sodium and fluid absorption in rat cortical collecting ducts?

Population

Microdissected and perfused rat cortical collecting ducts in vitro

Design

Preclinical

Authors

HNHiroshi NonoguchiNational Sagamihara HospitalJSJeff M. SandsEmory UniversityMKMark A. KnepperNational Institutes of Health

Discussion

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Implication

May explain ANF natriuresis in rodents; leaves open human relevance and clinical translation.

Structured PICO

Does ANF inhibit net sodium and fluid absorption in rat cortical collecting ducts?

P
Population
Microdissected and perfused rat cortical collecting ducts in vitro
I
Intervention
Atrial natriuretic factor (ANF-(1-28)) added to the peritubular bath solution (including 0.1 nM concentration)
O
Outcome
Net sodium absorption and vasopressin-stimulated net fluid absorptionsurrogate

ANF directly inhibits net sodium and fluid absorption in the cortical collecting duct, providing a mechanistic basis for its natriuretic and diuretic effects.

Cite This Study

Nonoguchi et al. (1989) studied this question.

synapsesocial.com/papers/6a7e4b4e971946435f4f9b29https://doi.org/10.1152/ajprenal.1989.256.1.f179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.1988 · 119 citations
  2. 2Atrial natriuretic factor plays a significant role in body fluid homeostasis.1990 · 81 citations
  3. 3Renal tubular actions of ANF1991 · 28 citations
  4. 4Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin1989 · 47 citations
  5. 5Atrial natriuretic factor can increase renal solute excretion primarily by raising glomerular filtration1986 · 99 citations