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September 1, 1988AJP Renal Physiology

Atrial natriuretic factor does not inhibit basal or angiotensin II-stimulated proximal transport

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Population

In vivo microperfusion model

Comparison

Systemic Atrial natriuretic factor vs Normal endogenous angiotensin II level or…

Design

Preclinical

Authors

FLF. Y. LiuUniversity of California, San FranciscoMCMartin G. CoganStanford University

Discussion

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Implication

ANF lacks direct proximal tubule effects in this rodent model; leaves open distal mechanisms of natriuresis and requires human validation.

Structured PICO

P
Population
In vivo microperfusion model
I
Intervention
Systemic Atrial natriuretic factor (ANF) (0.5 micrograms.kg-1.min-1)
C
Comparator
Normal endogenous angiotensin II level or transport stimulated by systemic angiotensin II administration (20 ng.kg-1.min-1)
O
Outcome
Bicarbonate, chloride, or water transport in the early or late proximal convoluted tubulesurrogate

Atrial natriuretic factor does not directly affect proximal tubule transport, consistent with the lack of high-affinity receptors in this region.

Cite This Study

Liu et al. (1988) studied this question.

synapsesocial.com/papers/6a7e4b4e971946435f4f9b2ahttps://doi.org/10.1152/ajprenal.1988.255.3.f434
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proceedings of the Symposium ‘Angiotensin AT1Receptors: From Molecular Physiology to Therapeutics’: REGULATION OF RENAL TUBULAR SODIUM TRANSPORT BY ANGIOTENSIN II AND ATRIAL NATRIURETIC FACTOR1996 · 38 citations
  2. 2ANF and angiotensin II interact via kinases in the proximal straight tubule1995 · 24 citations
  3. 3Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin1989 · 47 citations
  4. 4Interaction of atrial natriuretic factor and angiotensin II in proximal HCO3- reabsorption1992 · 18 citations
  5. 5Lack of a direct effect of atrial natriuretic factor in the rabbit proximal tubule1986 · 74 citations