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February 1, 1992AJP Renal Physiology

Interaction of atrial natriuretic factor and angiotensin II in proximal HCO3- reabsorption

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Population

Munich-Wistar rats (middle proximal tubule)

Comparison

Atrial natriuretic factor and angiotensin II… vs Control group or ANG II alone

Design

Preclinical

Authors

GGGuiomar Nascimento GomesUniversidade Federal de São PauloMAM. Mello AiresUniversidade de São Paulo

Discussion

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Implication

ANF may blunt ANG II effects on proximal acidification in rats; leaves open relevance to human cardiorenal acid-base disorders.

Structured PICO

P
Population
Munich-Wistar rats (middle proximal tubule)
I
Intervention
Atrial natriuretic factor (ANF) and angiotensin II (ANG II) infused systemically or added to luminal/peritubular perfusion fluid
C
Comparator
Control group (no infusion/perfusion) or ANG II alone
O
Outcome
Bicarbonate (HCO3-) reabsorption evaluated by acidification half timesurrogate

ANF alone does not affect proximal HCO3- reabsorption but impairs the stimulatory effect of ANG II.

Cite This Study

Gomes et al. (1992) studied this question.

synapsesocial.com/papers/6a8b24fee0eb9e4bd4f44471https://doi.org/10.1152/ajprenal.1992.262.2.f303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[NO TITLE AVAILABLE]1997
  2. 2Effect of luminal angiotensin II and ANP on early and late cortical distal tubule HCO3- reabsorption1996 · 76 citations
  3. 3Atrial natriuretic factor does not inhibit basal or angiotensin II-stimulated proximal transport1988 · 27 citations
  4. 4Renal response to atrial natriuretic factor is modulated by intrarenal angiotensin II1988 · 35 citations
  5. 5Dose-dependent effects of angiotensin-(1–7) on the NHE3 exchanger and [Ca<sup>2+</sup>]<sub>i</sub>in in vivo proximal tubules2013 · 31 citations