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April 1, 1997Brazilian Journal of Medical and Biological ResearchOpen Access

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Population

Rat middle proximal tubule, early and late distal tubules (in vivo), and MDCK cells (in vitro)

Comparison

Angiotensin II and Atrial natriuretic peptide vs Basal conditions / absence of hormones

Design

Preclinical

Authors

MMM. Mello-AiresUniversidade de São PauloMBMaria Luiza Morais Barreto‐ChavesUniversidade de São PauloGGGuiomar Nascimento GomesUniversidade Federal de São Paulo

Discussion

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Implication

Does not support clinical use in acid-base disorders; leaves open human translation of ANG II-ANP tubule effects.

Structured PICO

P
Population
Rat middle proximal tubule, early and late distal tubules (in vivo), and MDCK cells (in vitro)
I
Intervention
Angiotensin II (ANG II) and Atrial natriuretic peptide (ANP)
C
Comparator
Basal conditions / absence of hormones
O
Outcome
Kinetics of bicarbonate reabsorption, cell pH recovery, and intracellular free calcium concentrationsurrogate

This preclinical study demonstrates that ANP modulates the stimulatory effects of ANG II on bicarbonate reabsorption in the proximal tubule and intracellular calcium levels in MDCK cells.

Cite This Study

Mello-Aires et al. (1997) studied this question.

synapsesocial.com/papers/6a1bd1876f692abb725eea32https://doi.org/10.1590/s0100-879x1997000400007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interaction of atrial natriuretic factor and angiotensin II in proximal HCO3- reabsorption1992 · 18 citations
  2. 2Effect of luminal angiotensin II and ANP on early and late cortical distal tubule HCO3- reabsorption1996 · 76 citations
  3. 3Mechanism of acidification along cortical distal tubule of the rat1994 · 43 citations
  4. 4Atrial natriuretic factor does not inhibit basal or angiotensin II-stimulated proximal transport1988 · 27 citations
  5. 5Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin1989 · 47 citations