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December 1, 1988Journal of Hypertension

Interaction between atrial natriuretic factor and angiotensin II receptors in the regulation of blood pressure

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Population

Cultured vascular smooth muscle cells

Design

Preclinical

Follow-up

18 h (incubation time)

Authors

PCPierre‐Etienne ChabrierIpsen (France)PRPierre RoubertIpsen (France)MLMarie-Odi-Le Longchamps

Discussion

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Implication

Hypothesis-generating for Ang II-ANF crosstalk in hypertension models; leaves open translation to human disease.

Structured PICO

P
Population
Cultured vascular smooth muscle cells
I
Intervention
Angiotensin II (10(-8) mol/l) incubation for 18 h
O
Outcome
ANF receptor binding capacity and ANF-stimulated cyclic GMP formationsurrogate

Angiotensin II down-regulates ANF receptors while paradoxically increasing ANF biological activity, suggesting a compensatory mechanism against excessive Ang II pressor effects.

Cite This Study

Chabrier et al. (1988) studied this question.

synapsesocial.com/papers/6a7574e9f1e99ff85ab1edd5https://doi.org/10.1097/00004872-198812040-00089
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of atrial natriuretic factor receptors by angiotensin II in rat vascular smooth muscle cells.1988 · 74 citations
  2. 2Receptor Regulation of Atrial Natriuretic Factor2008 · 10 citations
  3. 3Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells1996 · 13 citations
  4. 4Modulation of ANF-R2 receptors by angiotensin II in vascular smooth muscle cells.1995
  5. 5Atrial natriuretic factor inhibits central angiotensin II pressor responses.1987 · 33 citations