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April 1, 1995American Journal of Hypertension

Modulation of ANF-R2 receptors by angiotensin II in vascular smooth muscle cells.

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Population

Vascular smooth muscle cells (VSMC A-10)

Comparison

Angiotensin II pretreatment, with or without… vs Untreated cells or cells without specific…

Design

Preclinical

Authors

APAnuradha PalapartiMontreal Neurological Institute and Hospital

Discussion

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Implication

Suggests PKC role in AII-ANF signaling in animal VSMCs; hypothesis-generating and leaves open relevance to human hypertension.

Structured PICO

P
Population
Vascular smooth muscle cells (VSMC A-10)
I
Intervention
Angiotensin II (AII) pretreatment, with or without losartan or staurosporin
C
Comparator
Untreated cells or cells without specific pretreatments
O
Outcome
Adenylyl cyclase activity and [125I]-ANF binding to ANF receptorssurrogate

Angiotensin II modulates ANF-R2 receptor-mediated inhibition of adenylyl cyclase in vascular smooth muscle cells via PKC-mediated uncoupling from Gi protein.

Cite This Study

Anuradha Palaparti (1995) studied this question.

synapsesocial.com/papers/6a7150afa7fbea1e44085fc3https://doi.org/10.1016/0895-7061(95)97993-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells1996 · 13 citations
  2. 2Regulation of atrial natriuretic factor receptors by angiotensin II in rat vascular smooth muscle cells.1988 · 74 citations
  3. 3Interaction between atrial natriuretic factor and angiotensin II receptors in the regulation of blood pressure1988 · 3 citations
  4. 4Receptor Regulation of Atrial Natriuretic Factor2008 · 10 citations
  5. 5Differential Regulation of ANF-R2 Receptors Coupled to Adenylyl Cyclase in Cardiovascular Tissues in Hypertension1993 · 6 citations