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June 1, 1993American Journal of Hypertension

Differential Regulation of ANF-R2 Receptors Coupled to Adenylyl Cyclase in Cardiovascular Tissues in Hypertension

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Key result

GTP gamma S stimulates adenylyl cyclase ~50% less in hypertensive rats, indicating differential ANF-R2 regulation.

Population

Spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats

Comparison

ANF99-126 and GTP gamma S vs WKY rats (normotensive controls)

Design

Preclinical

Authors

MAMadhu B. Anand‐SrivastavaUniversité de Montréal

Discussion

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Implication

Differential ANF-R2 regulation in SHR models is hypothesis-generating; leaves open relevance to human hypertension.

Structured PICO

P
Population
Spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats used to investigate ANF-R2 receptor regulation.
I
Intervention
ANF99-126 and GTP gamma S
C
Comparator
WKY rats (normotensive controls)
O
Outcome
Adenylyl cyclase activitysurrogate

ANF-R2 receptors in platelets from spontaneously hypertensive rats are differentially regulated compared to those in the heart and aorta.

Cite This Study

Madhu B. Anand‐Srivastava (1993) studied Hypertension. ANF99-126 and GTP gamma S vs. Wistar-Kyoto (WKY) rats was evaluated on Adenylyl cyclase activity. GTP gamma S stimulated adenylyl cyclase activity by about 300% in aorta from spontaneously hypertensive rats compared to about 600% in WKY rats, indicating differential ANF-R2 receptor regulation.

synapsesocial.com/papers/6aa2007fe42d107f4a3b3526https://doi.org/10.1093/ajh/6.6.538

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular atrial natriuretic factor receptors in spontaneously hypertensive rats1992 · 8 citations
  2. 2Modulation of ANF-R2 receptors by angiotensin II in vascular smooth muscle cells.1995
  3. 3Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells1996 · 13 citations
  4. 4Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition1992 · 132 citations
  5. 5The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. Coupling to adenylate cyclase/cyclic AMP signal-transduction system1991 · 44 citations