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September 1, 1996American Journal of Hypertension

Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells

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Population

Vascular smooth muscle cells (VSMC A-10)

Comparison

Angiotensin II pretreatment, with or without… vs Control vascular smooth muscle cells

Design

Preclinical

Authors

APAnuradha PalapartiMontreal Neurological Institute and Hospital

Discussion

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Implication

Hypothesis-generating for PKC-mediated ANF-R2 uncoupling in VSMCs; leaves open human relevance and therapeutic translation.

Structured PICO

P
Population
Vascular smooth muscle cells (VSMC A-10)
I
Intervention
Angiotensin II (AII) pretreatment, with or without losartan or staurosporine
C
Comparator
Control vascular smooth muscle cells
O
Outcome
Adenylyl cyclase activity and ANF-R2 receptor modulationsurrogate

Angiotensin II modulates ANF-R2 receptor-mediated inhibition of adenylyl cyclase in vascular smooth muscle cells via PKC-mediated uncoupling from the Gi protein.

Cite This Study

Anuradha Palaparti (1996) studied this question.

synapsesocial.com/papers/6a71466df44fa9f079df0effhttps://doi.org/10.1016/s0895-7061(96)00108-2
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Also Consider

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