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April 1, 1995AJP Renal Physiology

ANF and angiotensin II interact via kinases in the proximal straight tubule

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Population

Proximal straight tubule (PST)

Comparison

Atrial natriuretic factor (ANF) 10(-10) M vs Angiotensin II alone or other kinase…

Design

Preclinical

Authors

NGNéstor H. GarcíaInstituto de Investigaciones en Ciencias de la SaludJGJeffrey L. GarvinUniversity School

Discussion

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Implication

ANF may oppose ANG II effects on proximal reabsorption; leaves open translation from this animal model to human cardiorenal therapy.

Structured PICO

P
Population
Proximal straight tubule (PST)
I
Intervention
Atrial natriuretic factor (ANF) 10(-10) M
C
Comparator
Angiotensin II (ANG II) alone or other kinase inhibitors/mimics without ANF
O
Outcome
Fluid absorption (Jv)surrogate

ANF inhibits ANG II-induced stimulation of fluid absorption in the proximal straight tubule via a mechanism requiring cGMP-dependent protein kinase phosphorylation after a decrease in PKA activity.

Cite This Study

García et al. (1995) studied this question.

synapsesocial.com/papers/6a843ce1c2c8a33f31f7a05ahttps://doi.org/10.1152/ajprenal.1995.268.4.f730
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin1989 · 47 citations
  2. 2Atrial natriuretic factor does not inhibit basal or angiotensin II-stimulated proximal transport1988 · 27 citations
  3. 3Regulation of atrial natriuretic factor receptors by angiotensin II in rat vascular smooth muscle cells.1988 · 74 citations
  4. 4ANF inhibits norepinephrine-stimulated fluid absorption in rat proximal straight tubules1992 · 12 citations
  5. 5Modulation of ANF-R2 receptors by angiotensin II in vascular smooth muscle cells.1995