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September 1, 1988Journal of Biological ChemistryOpen Access

Regulation of atrial natriuretic factor receptors by angiotensin II in rat vascular smooth muscle cells.

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Population

Rat cultured vascular smooth muscle cells

Comparison

Long term pretreatment with Angiotensin II vs Control and other agents

Design

Preclinical

Follow-up

18 hours

Authors

PCP ChabrierIpsen (France)PRPierre RoubertIpsen (France)MLMarie-Odile LonchamptIpsen (France)

Discussion

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Implication

Ang-II downregulates non-GC ANF receptors in rat cells; hypothesis-generating for RAAS-natriuretic peptide crosstalk in vivo.

Structured PICO

P
Population
Rat cultured vascular smooth muscle cells
I
Intervention
Long term pretreatment (18 h) with Angiotensin II (1, 10, and 100 nM)
C
Comparator
Control (no pretreatment) and other agents (100 nM of epinephrine, norepinephrine, histamine, serotonin, and Arg-vasopressin)
O
Outcome
Binding of 125I-labeled ANF (number of ANF binding sites, Bmax) and cyclic GMP production induced by ANFsurrogate

Angiotensin II specifically down-regulates non-guanylate cyclase-coupled ANF receptors in rat vascular smooth muscle cells, demonstrating a functional link between the two systems.

Cite This Study

Chabrier et al. (1988) studied this question.

synapsesocial.com/papers/6a71487426a7f98052ddaa83https://doi.org/10.1016/s0021-9258(18)37691-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interaction between atrial natriuretic factor and angiotensin II receptors in the regulation of blood pressure1988 · 3 citations
  2. 2Receptor Regulation of Atrial Natriuretic Factor2008 · 10 citations
  3. 3Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells1996 · 13 citations
  4. 4Modulation of ANF-R2 receptors by angiotensin II in vascular smooth muscle cells.1995
  5. 5Angiotensin II and Atrial Natriuretic Factor-Binding Sites in Various Tissues in Hypertension: Comparative Receptor Localization and Changes in Different Hypertension Models in the Rat*1989 · 24 citations