Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1990Journal of Biological ChemistryOpen Access

Vascular atrial natriuretic factor receptor subtypes are not independently regulated by atrial peptides.

View Full Paper
Ask AI
Bookmark
Share

Population

Cultured rat vascular smooth muscle cells (RVSMC)

Design

Preclinical

Follow-up

24 hours

Authors

PCPaul A. CahillUniversity of Rochester Medical CenterEREileen M. RedmondUniversity of Rochester Medical CenterAKA. K. KeenanUniversity of Strathclyde

Discussion

Loading...

Member takes

Implication

May indicate cooperative ANF-C receptor regulation by nonselective ligands in vitro; leaves open translational relevance to human vascular signaling.

Structured PICO

P
Population
Cultured rat vascular smooth muscle cells (RVSMC)
I
Intervention
Pretreatment for 24 h with rANF99-126 or truncated and ring-deleted analogs
O
Outcome
Number of ANF binding sites and particulate guanylate cyclase activity/cGMP productionsurrogate

ANF-C receptors in rat vascular smooth muscle cells are not independently down-regulated by selective ligands, but nonselective analogs that down-regulate the ANF-B receptor system can cooperatively reduce the ANF-C receptor pool.

Cite This Study

Cahill et al. (1990) studied this question.

synapsesocial.com/papers/6a7ea09d6cdd7a4db302650bhttps://doi.org/10.1016/s0021-9258(18)45823-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of structural requirements for analogs of atrial natriuretic peptide (ANP) to discriminate between ANP receptor subtypes1989 · 30 citations
  2. 2Effects of alpha-human atrial natriuretic peptide in essential hypertension.1985 · 123 citations
  3. 3Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.1980 · 794 citations
  4. 4Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis.1988 · 103 citations
  5. 5Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells.1986 · 228 citations