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March 1, 1991AJP Cell Physiology

Characterization of ANF receptors in cultured renal cortical vascular smooth muscle cells

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Population

Subcultured vascular smooth muscle cells (VSMC) prepared from the rabbit renal cortex

Design

Preclinical

Authors

MBMarie-Luce BéaUniversité Paris-SudJDJean‐Claude DussauleCross-Cutting CardiologyMBMarcelle BensCentre National de la Recherche Scientifique

Discussion

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Implication

Supports ANF-cGMP signaling in renal vascular cells; extends in vivo data but leaves open human translation.

Structured PICO

P
Population
Subcultured vascular smooth muscle cells (VSMC) prepared from the rabbit renal cortex
I
Intervention
Atrial natriuretic factor (ANF), [Ala7,Ala23]ANF, and C-ANF-(4-23)
O
Outcome
125I-ANF binding and ANF-dependent guanosine 3',5'-cyclic monophosphate (cGMP) productionsurrogate

ANF binds to high-affinity receptors and markedly stimulates cGMP accumulation in cultured rabbit renal cortical vascular smooth muscle cells.

Cite This Study

Béa et al. (1991) studied this question.

synapsesocial.com/papers/6a1eb53e94615786b59a73cfhttps://doi.org/10.1152/ajpcell.1991.260.3.c424
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli.1985 · 229 citations
  2. 2Renal mechanism of action of rat atrial natriuretic factor.1985 · 247 citations
  3. 3Physiological Role of Silent Receptors of Atrial Natriuretic Factor1987 · 940 citations
  4. 4Atrial natriuretic factor and cyclic guanosine 3',5'-monophosphate in vascular smooth muscle.1986 · 26 citations
  5. 5Modulation of the natriuretic response to atrial natriuretic peptide by alterations in peritubular Starling forces in the rat.1986 · 40 citations