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January 1, 1993Journal of Cellular Physiology

Differential antimitogenic effectiveness of atrial natriuretic peptides in primary versus subcultured rat aortic smooth muscle cells: Relationship to expression of ANF‐C receptors

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Population

Rat aortic smooth muscle cells (primary cultures and subcultured cells between subcultures 3 and 25)

Comparison

Atrial natriuretic peptides vs Comparison between primary and subcultured cells

Design

Preclinical

Authors

PCPaul A. CahillUniversity of Rochester Medical CenterAHAviv HassidUniversity of Tennessee Health Science Center

Discussion

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Implication

Antimitogenic effects of atrial peptides depend on smooth muscle cell phenotype; hypothesis-generating for vascular biology but should not yet change practice.

Structured PICO

P
Population
Rat aortic smooth muscle cells (primary cultures and subcultured cells between subcultures 3 and 25)
I
Intervention
Atrial natriuretic peptides (rANF99-126, rANF103-126, rANF103-125, Cys116rANF102-116, and des[Cys105,Cys121] rANF104-126)
C
Comparator
Comparison between primary and subcultured cells
O
Outcome
Inhibition of serum-induced [3H]thymidine incorporation (antimitogenic effect) and ANF receptor expression/binding affinitysurrogate

The antimitogenic effectiveness of atrial natriuretic peptides in aortic smooth muscle cells is dependent on the phenotypic state of the cells, driven by increased expression of ANF-C-type receptors during subculture.

Cite This Study

Cahill et al. (1993) studied this question.

synapsesocial.com/papers/6a98fb48b3d4f622baf0cedahttps://doi.org/10.1002/jcp.1041540105
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for Atrial Natriuretic Peptide-(5–28) Production by Macrophages of the Rat Spleen: An Immunochemical and Nonradioactivein SituHybridization Approach*1991 · 30 citations
  2. 2Vascular atrial natriuretic factor receptor subtypes are not independently regulated by atrial peptides.1990 · 60 citations
  3. 3Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.1989 · 2,172 citations
  4. 4The hydrolysis of α-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.111987 · 287 citations
  5. 5Identification of a receptor for atrial natriuretic factor in rabbit aorta membranes by affinity cross-linking.1985 · 95 citations