January 1, 1994AJP Regulatory Integrative and Comparative Physiology

ANF-C-receptor-mediated inhibition of aortic smooth muscle cell proliferation and thymidine kinase activity

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Population

Subcultured aortic smooth muscle cells, cultured rat mesangial cells, and bovine pulmonary artery…

Comparison

Rat atrial natriuretic factor [rANF-] and… vs Control or cANF

Design

Preclinical

Authors

PCPaul A. CahillUniversity of Rochester Medical Center AHAviv HassidUniversity of Tennessee Health Science Center

Discussion

Member takes

Implication

Hypothesis-generating for ANP C-receptor effects on VSMC growth in animals; leaves open any human vascular disease relevance.

Structured PICO

Population

Subcultured aortic smooth muscle cells, cultured rat mesangial cells, and bovine pulmonary artery endothelial cells

Intervention

Rat atrial natriuretic factor [rANF-(99-126)] and synthetic peptides binding to ANF-C-type clearance receptors

Comparator

Control (serum-induced mitogenesis without peptides) or cANF

Outcome

DNA synthesis ([3H]thymidine incorporation), cell proliferation, and thymidine kinase activitysurrogate

Atrial natriuretic peptide analogues inhibit vascular smooth muscle cell proliferation via a cyclic nucleotide-independent mechanism involving the C-type receptor.

Cite This Study

Cahill et al. (1994) studied this question.

synapsesocial.com/papers/6a85467eff13e6e4e743ddee https://doi.org/10.1152/ajpregu.1994.266.1.r194

View Full Paper

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ANF-C-receptor-mediated inhibition of aortic smooth muscle cell proliferation and thymidine kinase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ANF-C-receptor-mediated inhibition of aortic smooth muscle cell proliferation and thymidine kinase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider