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May 1, 1990Journal of Biological ChemistryOpen Access

Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system.

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Population

Rat tissues, vascular smooth muscle cells, and MA-10 cell line

Design

Preclinical

Authors

MAMadhu B. Anand‐SrivastavaUniversité de MontréalMSM.R. SairamUniversidade Federal de Minas GeraisMCM. CantinHeart Failure / Cardiomyopathy

Discussion

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Implication

No immediate clinical implications; hypothesis-generating for ANF-R2 receptor coupling to adenylate cyclase inhibition in vascular cells.

Structured PICO

P
Population
Rat tissues (aorta, brain striatum, anterior pituitary, adrenal cortical membranes), vascular smooth muscle cells, and MA-10 cell line
I
Intervention
Ring-deleted analogs of atrial natriuretic factor (C-ANF4-23 and other smaller fragments)
O
Outcome
Adenylate cyclase activity and cAMP levelssurrogate

Ring-deleted analogs of atrial natriuretic factor inhibit the adenylate cyclase/cAMP system, indicating that ANF-R2 (clearance) receptors are coupled to this signal transduction pathway via an inhibitory guanine nucleotide regulatory protein.

Cite This Study

Anand‐Srivastava et al. (1990) studied this question.

synapsesocial.com/papers/6a70f2db26a7f98052dd6571https://doi.org/10.1016/s0021-9258(19)38925-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physiological Role of Silent Receptors of Atrial Natriuretic Factor1987 · 940 citations
  2. 2Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues.1984 · 675 citations
  3. 3The Role of Cyclic Nucleotides in Atrial Natriuretic Peptide-Mediated Inhibition of Aldosterone Secretion*1988 · 57 citations
  4. 4Involvement of Ni protein in the functional coupling of the atrial natriuretic factor (ANF) receptor to adenylate cyclase in rat lung plasma membranes1988 · 22 citations
  5. 5Inhibitory effect of atrial natriuretic factor on adenylate cyclase activity in adrenal cortical membranes1985 · 62 citations