What does this research mean for the field?

Atrial natriuretic factor (ANF) inhibits mitogenesis in rat mesangial cells in a dose-dependent manner, an effect that is absent in cells possessing only clearance ANF receptors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1990AJP Endocrinology and Metabolism

Mechanism of atrial natriuretic factor-induced inhibition of rat mesangial cell mitogenesis.

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Why the study?

Does atrial natriuretic factor inhibit mitogenesis in rat mesangial cells and 3T3 fibroblasts?

Population

Rat mesangial cells and 3T3 fibroblasts

Comparison

Atrial natriuretic factor, 8-bromoguanosine… vs Vehicle

Design

Preclinical

Follow-up

3 days

Authors

RARichard G. AppelMichael E. DeBakey VA Medical Center

Discussion

Member takes

Implication

Hypothesis-generating for ANF growth inhibition in mesangial cells; leaves open in vivo relevance to glomerular disease.

Structured PICO

Does atrial natriuretic factor inhibit mitogenesis in rat mesangial cells and 3T3 fibroblasts?

Population

Rat mesangial cells (which have both biological and clearance ANF receptors) and 3T3 fibroblasts (which have only clearance ANF receptors)

Intervention

Atrial natriuretic factor (ANF), 8-bromoguanosine 3',5'-cyclic monophosphate, or sodium nitroprusside

Comparator

Vehicle

Outcome

[3H]thymidine uptake and intracellular cGMP accumulationsurrogate

Atrial natriuretic factor inhibits mitogenesis in rat mesangial cells but not in 3T3 fibroblasts, an effect associated with intracellular cGMP accumulation.

Cite This Study

Richard G. Appel (1990) studied this question.

synapsesocial.com/papers/6a1ec4adbf2a5d44faaf4bec https://doi.org/10.1152/ajpendo.1990.259.3.e312

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Mechanism of atrial natriuretic factor-induced inhibition of rat mesangial cell mitogenesis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of atrial natriuretic factor-induced inhibition of rat mesangial cell mitogenesis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider