January 1, 1990AJP Cell Physiology

Atrial natriuretic factor alters phospholipid metabolism in mesangial cells

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Population

Cultured rat mesangial cells (MCs)

Comparison

Atrial natriuretic factor and Sodium nitroprusside vs Angiotensin II (ANG II) alone

Design

Preclinical

Authors

RBRichard BarnettDonald & Barbara Zucker School of Medicine at Hofstra/Northwell POPhillip OrtizPurchase College SBS. BlaufoxStony Brook University

Discussion

Member takes

Implication

ANF-ANG II interactions in animal mesangial cells remain preclinical; leaves open any role in human glomerular disease or therapy.

Structured PICO

Population

Cultured rat mesangial cells (MCs)

Intervention

Atrial natriuretic factor (ANF) and Sodium nitroprusside (SNP)

Comparator

Angiotensin II (ANG II) alone

Outcome

Intracellular calcium metabolism, inositol trisphosphate (IP3) release, cytosolic free Ca2+, 45Ca efflux/influx, phospholipid turnover, and prostaglandin E2 releasesurrogate

ANF antagonizes ANG II-induced calcium mobilization and phospholipid turnover in mesangial cells via cGMP-mediated pathways.

Cite This Study

Barnett et al. (1990) studied this question.

synapsesocial.com/papers/6a7624d4b515f78917fbdda5 https://doi.org/10.1152/ajpcell.1990.258.1.c37

View Full Paper

Ask AI

Bookmark

Atrial natriuretic factor alters phospholipid metabolism in mesangial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atrial natriuretic factor alters phospholipid metabolism in mesangial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider