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November 30, 1987FEBS LettersOpen Access

Effect of atrial natriuretic factor on cytosolic free calcium in rat glomerular mesangial cells

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Why the study?

Does atrial natriuretic factor reduce cytosolic free calcium in rat glomerular mesangial cells?

Population

Rat glomerular mesangial cells (fura-2-loaded monolayers)

Comparison

Atrial natriuretic factor (ANF) vs Buffer

Design

Preclinical

Authors

RARichard G. AppelMichael E. DeBakey VA Medical CenterGDGeorge DubyakCase Western Reserve UniversityMDMichael J. DünnBrigham Young University

Discussion

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Implication

Hypothesis-generating for ANF in mesangial calcium signaling; leaves open in vivo and human relevance.

Structured PICO

Does atrial natriuretic factor reduce cytosolic free calcium in rat glomerular mesangial cells?

P
Population
Rat glomerular mesangial cells (fura-2-loaded monolayers)
I
Intervention
Atrial natriuretic factor (ANF)
C
Comparator
Buffer
O
Outcome
Cytosolic free calcium levels (basal and angiotensin II-induced)surrogate

ANF lowers basal and ANGII-induced cytosolic free calcium in mesangial cells, though its vasorelaxant effects may involve additional mechanisms.

Cite This Study

Appel et al. (1987) studied this question.

synapsesocial.com/papers/6a83fadebe1bfc07a3fe1695https://doi.org/10.1016/0014-5793(87)80491-x
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