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September 1, 1988AJP Renal Physiology

Hormone effects on NaCl permeability of rat inner medullary collecting duct

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Key result

Atrial natriuretic factor reduces chloride permeability without altering sodium permeability in rat collecting ducts.

Population

Isolated perfused terminal inner medullary collecting ducts (IMCDs) from rats (control and DOC-treated)

Comparison

Atrial natriuretic factor [rat ANF-, 100 nM in… vs Baseline/control conditions

Design

Preclinical

Authors

JSJeff M. SandsEmory UniversityHNHiroshi NonoguchiNational Sagamihara HospitalMKMark A. KnepperNational Institutes of Health

Discussion

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Implication

Challenges hypothesis that ANF increases IMCD NaCl permeability; animal data leave mechanism open and should not guide practice.

Structured PICO

P
Population
Isolated perfused terminal inner medullary collecting ducts from rats.
I
Intervention
Atrial natriuretic factor (ANF) [rat ANF-(1-28), 100 nM in peritubular bath], vasopressin (10 nM in peritubular bath), or deoxycorticosterone (DOC) treatment
C
Comparator
Baseline/control conditions
O
Outcome
Apparent Cl- or Na+ permeabilities (PCl and PNa) and transepithelial resistance (RT)surrogate

ANF decreases chloride permeability rather than increasing NaCl permeability in the terminal IMCD, challenging the hypothesis that ANF causes natriuresis via increased IMCD NaCl permeability.

Cite This Study

Sands et al. (1988) studied this question. Atrial natriuretic factor (ANF), vasopressin, or deoxycorticosterone (DOC) vs. Control was evaluated on Apparent Cl- or Na+ permeabilities (PCl and PNa) and Transepithelial resistance (RT). In isolated rat inner medullary collecting ducts, atrial natriuretic factor significantly decreased chloride permeability without altering sodium permeability.

synapsesocial.com/papers/6aa6e06d8d01e9f7b27f2118https://doi.org/10.1152/ajprenal.1988.255.3.f421
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial peptide and cGMP effects on NaCl transport in inner medullary collecting duct1990 · 60 citations
  2. 2Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.1988 · 119 citations
  3. 3Atrial natriuretic peptides inhibit conductive sodium uptake by rabbit inner medullary collecting duct cells.1988 · 150 citations
  4. 4ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney1989 · 82 citations
  5. 5Effect of dietary salt on neuronal nitric oxide synthase in the inner medullary collecting duct1998 · 58 citations