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April 1, 1988AJP Renal Physiology

Micropuncture study of the effect of ANP on the papillary collecting duct in the rat

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Why the study?

Does ANP infusion affect sodium delivery and reabsorption in the terminal collecting duct in rats?

Population

Rats (micropuncture study of the terminal collecting duct at base and tip of the renal papilla)

Comparison

Infusion with atrial natriuretic peptide (ANP) vs Vehicle only or acetazolamide

Design

Preclinical

Authors

ASAnja van de StolpeFuture Diagnostics (Netherlands)RJR. L. JamisonMedical Council of Canada

Discussion

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Implication

ANP natriuresis mechanisms remain preclinical; leaves open translation to human sodium handling.

Structured PICO

Does ANP infusion affect sodium delivery and reabsorption in the terminal collecting duct in rats?

P
Population
Rats (micropuncture study of the terminal collecting duct at base and tip of the renal papilla)
I
Intervention
Infusion with atrial natriuretic peptide (ANP)
C
Comparator
Vehicle only or acetazolamide
O
Outcome
Sodium delivery and reabsorption in the terminal collecting ductsurrogate

This preclinical study demonstrates that ANP induces natriuresis by both increasing sodium delivery to and inhibiting sodium reabsorption in the terminal collecting duct.

Cite This Study

Stolpe et al. (1988) studied this question.

synapsesocial.com/papers/6a8b27f7c12eaf65c8b1fd1ehttps://doi.org/10.1152/ajprenal.1988.254.4.f477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tubular site(s) of action of atrial natriuretic peptide in the rat1988 · 21 citations
  2. 2Effect of synthetic ANP on renal and loop of Henle functions in the young rat1986 · 47 citations
  3. 3Effect of atrial natriuretic peptide on vasa recta blood flow in the rat1987 · 51 citations
  4. 4EFFECT OF ATRIAL NATRIURETIC PEPTIDE ON CELLULAR ELEMENT CONCENTRATIONS IN RAT PROXIMAL TUBULES: EVIDENCE FOR INHIBITION OF THE SODIUM PUMP1994 · 4 citations
  5. 5Effects of atrial natriuretic peptide (ANP) during converting enzyme inhibition1987 · 15 citations