June 1, 1987AJP Renal Physiology

Effect of atrial natriuretic peptide on vasa recta blood flow in the rat

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Population

Anesthetized Munich Wistar rats weighing between 102 and 161 g, maintained in a euvolemic state by albumin…

Design

Preclinical

Follow-up

45 minutes

Authors

BKB. KiberdDalhousie University TLT. S. LarsonMayo Clinic in Arizona CRC R RobertsonPenn State Milton S. Hershey Medical Center

Discussion

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Implication

ANP augments medullary flow in rats; hypothesis-generating for natriuresis mechanisms, no human translation yet.

Structured PICO

Population

Anesthetized Munich Wistar rats weighing between 102 and 161 g, maintained in a euvolemic state by albumin infusion (n=7 in experimental group)

Intervention

Synthetic atrial natriuretic peptide (ANP, Auriculin B) administered intravenously as 2.5 micrograms/kg body wt prime and continuous infusion of 0.2 microgram/min/kg body wt

Outcome

Inner medullary vasa recta blood flow (descending and ascending), urine flow, and sodium excretionsurrogate

Synthetic ANP increases renal medullary blood flow, urine flow, and sodium excretion in a rat model.

Cite This Study

Kiberd et al. (1987) studied this question.

synapsesocial.com/papers/6a71edcaf44fa9f079df959b https://doi.org/10.1152/ajprenal.1987.252.6.f1112

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Effect of atrial natriuretic peptide on vasa recta blood flow in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of atrial natriuretic peptide on vasa recta blood flow in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider