Population
Human microvascular endothelial cells (HMECs), isolated perfused rat kidney, and Wistar-Kyoto rats
Design
Preclinical
Authors
Loading...
Highlights novel endothelial vasoconstrictor pathway in animals; leaves open its role in human hypertension and P2X1 as therapeutic target.
Adenosine 5'-tetraphosphate (AP4) is a highly potent endogenous endothelium-derived vasoconstrictor acting via the P2X1 receptor.
Tölle et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: