Why the study?
Does diadenosine monophosphate (AP1A) alter the force of contraction in isolated human atrial preparations?
Population
Isolated electrically driven (0.5 Hz) preparations from human atria (n=5-8)
Comparison
Diadenosine monophosphate at various… vs Predrug baseline and isoprenaline alone
Design
Preclinical
Follow-up
minutes (acute incubation)
Authors
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May blunt excessive beta-adrenergic inotropy in atrium; leaves open clinical translation from animal data.
Does diadenosine monophosphate (AP1A) alter the force of contraction in isolated human atrial preparations?
AP1A exerts direct and indirect negative inotropic effects in the human heart via A1-adenosine receptors, potentially protecting against excessive beta-adrenergic stimulation.
Zimmermann et al. (2000) studied this question.
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