What does this research mean for the field?

Stimulation of the adenosine A2A receptor attenuates adenosine A1 receptor-dependent reductions in cardiac contractility through the stimulation of adenylyl cyclase activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 29, 2009Clinical and Experimental Pharmacology and PhysiologyOpen Access

Adenosine receptor interactions alter cardiac contractility in rat heart

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Why the study?

Does DPMA alter AdoA1R-mediated negative inotropic responses in isolated rat hearts?

Population

Hearts from male Wistar rats (250-350 g) perfused in Langendorff mode

Comparison

DPMA (adenosine A2 receptor agonist) 1 nmol/L vs Control hearts (absence of DPMA)

Design

Preclinical

Authors

RRRoselyn B. Rose’MeyerGriffith University

Discussion

Member takes

Implication

May attenuate A1-mediated negative inotropy via A2A in rat hearts; leaves open translation to human physiology.

Structured PICO

Does DPMA alter AdoA1R-mediated negative inotropic responses in isolated rat hearts?

Population

Hearts from male Wistar rats (250-350 g) perfused in Langendorff mode

Intervention

DPMA (adenosine A2 receptor agonist) 1 nmol/L

Comparator

Control hearts (absence of DPMA)

Outcome

Concentration-dependent decreases in triple product (heart rate x peak systolic developed pressure x dP/dt(max)) induced by R-PIAsurrogate

Stimulation of the adenosine A2A receptor attenuates A1 receptor-dependent reductions in cardiac inotropic state via adenylyl cyclase activation.

Cite This Study

Roselyn B. Rose’Meyer (2009) studied this question.

synapsesocial.com/papers/6a197aa1c05413006f58644e https://doi.org/10.1111/j.1440-1681.2009.05228.x

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Adenosine receptor interactions alter cardiac contractility in rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine receptor interactions alter cardiac contractility in rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider