What does this research mean for the field?

Adenosine A2a receptors are present in rat ventricular myocytes and their stimulation increases inotropy through both cAMP-dependent and cAMP-independent mechanisms. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1997Cardiovascular ResearchOpen Access

Adenosine A2 receptor function in rat ventricular myocytes

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Why the study?

Does adenosine A2 receptor stimulation increase inotropy in rat ventricular myocytes?

Structured PICO

Does adenosine A2 receptor stimulation increase inotropy in rat ventricular myocytes?

Population

Isolated contracting rat ventricular myocytes

Intervention

Adenosine A2 receptor agonists (CGS-21680, NECA, SHA-082, and adenosine in the presence of DPCPX)

Comparator

A2 receptor antagonists (CGS-15943 and CSC) or baseline

Outcome

Contractile responses (myocyte inotropy, shortening, duration of shortening, time-to-peak shortening, time-to-75% relaxation, rate of maximal shortening), adenylyl cyclase activity, and cyclic AMP levelssurrogate

Adenosine A2a receptors are present in rat ventricular myocytes and mediate an increase in inotropy via cAMP-dependent and -independent mechanisms.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

A2 agonism may enhance rat myocyte contractility; leaves open therapeutic relevance in human HF pending translational studies.

Cite This Study

James G. Dobson (1997) studied this question.

synapsesocial.com/papers/6a197aa3c05413006f58645b https://doi.org/10.1016/s0008-6363(97)00023-0

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Adenosine A2 receptor function in rat ventricular myocytes

Structured PICO

Discussion

Implication

Cite This Study

Adenosine A2 receptor function in rat ventricular myocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider