May 1, 1996AJP Heart and Circulatory Physiology

Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte

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Population

Adult rat cardiac ventricular myocytes

Design

Preclinical

Authors

HXHaineng XuWenzhou University BSBarry SteinHartford Hospital BLBruce T. LiangHeart Failure / Cardiomyopathy

Discussion

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Implication

Supports A2a-mediated contractility in rat myocytes; hypothesis-generating for human HF with no clinical implications yet.

Structured PICO

Population

Adult rat cardiac ventricular myocytes

Intervention

A2a-receptor-selective agonist CGS-21680, nonselective agonists NECA and adenosine, and A2a-receptor-selective antagonist 8-(3-chlorostyryl)caffeine

Outcome

Myocyte contractile amplitude and adenosine 3',5'-cyclic monophosphate (cAMP) levelssurrogate

Adenosine A2a receptors are expressed and functionally coupled to the stimulation of cAMP accumulation and cardiac contractility in adult rat ventricular myocytes.

Cite This Study

Xu et al. (1996) studied this question.

synapsesocial.com/papers/6a197aa3c05413006f58645e https://doi.org/10.1152/ajpheart.1996.270.5.h1655

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Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider