2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy

Arran Babbs; Adam Berg; Maria Chatzopoulou; Kay E. Davies; Stephen G. Davies; Benjamin Edwards; David J. Elsey; Enrico Emer; Simon Guiraud; Shawn Harriman; Cristina Lecci; Lee Moir; David G. Peters; Neil Robinson; Jessica A. Rowley; Angela J. Russell; Sarah Squire; Jonathon M. Tinsley; Francis X. Wilson; Graham M. Wynne

doi:10.1021/acs.jmedchem.0c00807

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Abstract

and its enantiomers exhibited limited off-target effects, resulting in a safe profile and highlighting their potential utility as next-generation utrophin modulators suitable for progression toward a future DMD therapy.

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Babbs et al. (2020) studied this question.

synapsesocial.com/papers/6a025374ad92621f93b3643a https://doi.org/10.1021/acs.jmedchem.0c00807

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2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy

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2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy

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