Key result
GLS-based speckle tracking predicts LV dysfunction with an AUC of ~0.96 in cohort study.
Why the study?
Aortic stenosis often leads to left ventricular dysfunction that may remain undetected by conventional echocardiography, necessitating evaluation of speckle tracking echocardiography for prediction.
Does speckle tracking echocardiography predict left ventricular dysfunction in patients with severe aortic stenosis?
Cohort (n=100)
Does speckle tracking echocardiography predict left ventricular dysfunction in patients with severe aortic stenosis?
Absolute Event Rate: 68% vs 38%
p-value: p=0.003
Speckle tracking echocardiography demonstrates high sensitivity and specificity for detecting subclinical left ventricular dysfunction in severe aortic stenosis, suggesting potential benefits for early intervention in asymptomatic patients.
Background: Aortic stenosis (AS) often leads to left ventricular dysfunction (LVD), which may remain undetected by conventional echocardiography.Aim: To evaluate the role of speckle tracking echocardiography (STE) in predicting LVD in individuals with severe AS (SAS).Methods: This prospective cohort study encompassed 100 individuals with SAS, divided into asymptomatic (n=50) and symptomatic (n=50) groups. Conventional echocardiography and STE were carried out at baseline and after six months. Global longitudinal strain (GLS) and global circumferential strain (GCS) were assessed.Results: LVD was significantly higher in asymptomatic individuals (68% vs 38%, p=0.003). At baseline, asymptomatic individuals had better GLS (-22.32±4.43% vs -16.94±12.69%, p=0.006). However, after six months, GLS deteriorated significantly in asymptomatic individuals (-9.22±17.54% vs -19.78±15.16%, p=0.002). Similar trends were observed for GCS. GLS ≤-19% predicted LVD with 94.34% sensitivity and 87.23% specificity (AUC=0.962, p<0.001).Conclusion: STE demonstrates superior sensitivity in detecting subclinical LVD in SAS, particularly in asymptomatic individuals. The rapid deterioration of myocardial function in asymptomatic patients challenges traditional management approaches and suggests potential benefits of early intervention guided by STE parameters.
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A 2025 study conducted a cohort in Severe aortic stenosis (n=100). Asymptomatic status vs. Symptomatic status was evaluated on Left ventricular dysfunction (p=0.003). Speckle tracking echocardiography (GLS ≤-19%) predicted left ventricular dysfunction (AUC=0.962), which occurred more frequently in asymptomatic versus symptomatic patients (68% vs 38%, P=0.003).
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