An epicardial 3D panoramic optical mapping tool integrated with micro-CT and deep learning enabled analysis of electrical activity across the entire epicardial surface with 1 ms temporal resolution.
Integration of 3D panoramic optical mapping with micro-CT and deep learning enables high-resolution visualization of arrhythmogenic substrates in mouse hearts.
Electrical and structural remodeling of the heart can contribute to the development of cardiac arrhythmias. Ex vivo optical mapping has been used to visualize cardiac electrophysiological properties, activation and phase maps to further elucidate the mechanisms of atrial fibrillation and ventricular fibrillation initiation and persistence. Here we show an epicardial three-dimensional panoramic optical mapping tool integrated with micro-computed tomography automatically segmented with a deep learning model relying on a convolutional neural network to provide structural and electrical activation information in a single three-dimensional volume of a mouse heart. This technique allows for the acquisition and analysis of electrical activity of the entire epicardial surface with submillimeter spatial resolution and a temporal resolution of 1 ms. We establish the use of this method in transgenic mouse hearts with spontaneous atrial fibrillation and ventricular fibrillation, and mouse surgical models of myocardial infarction and left ventricular hypertrophy.
Melki et al. (Mon,) conducted a other in Cardiac arrhythmias (mouse models). Epicardial three-dimensional panoramic optical mapping integrated with micro-computed tomography was evaluated on Acquisition and analysis of electrical activity of the entire epicardial surface. An epicardial 3D panoramic optical mapping tool integrated with micro-CT and deep learning enabled analysis of electrical activity across the entire epicardial surface with 1 ms temporal resolution.
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