Key result
Single-cell transcriptomics reveals a conserved two-phase mechanism driving progression to right ventricular failure.
Identifies a conserved cross-species mechanistic framework characterized by two distinct phases of transcriptional changes underlying the progression from preserved right ventricular function to failure.
Answers are grounded in this paper and cite their sources.
Does not yet alter RV failure management; extends single-cell atlases by defining phased transcriptional transitions in human-mouse models.
RNA-sequencing analyses of right ventricular tissue from pediatric and adult patients, together with a mouse model of isolated pulmonary pressure overload, identify a conserved cross-species mechanistic framework that underlies progression from preserved right ventricular function to failure, characterized by two distinct phases of transcriptional changes.
No takes yet. Share an insight, caveat, or question.
A 2026 study studied this question. Integrated single-cell transcriptomics of human and mouse right ventricular tissue revealed a conserved two-phase transcriptional mechanism underlying progression to right ventricular failure.
Synapse has enriched 10 related papers. Consider them for comparative context: